For preoperative treatment, selective arterial injection chemoradiotherapy (arterial injection therapy) for the primary focus and lymph node metastasis has been performed in our department. In this study, we investigated the therapeutic effects of arterial injection therapy on lymph node metastasis. For arterial injection, we employed Seldinger's method. Initially, the dose of CBDCA was calculated using Calvert's formula. After a catheter was inserted into a nourishing blood vessel of the lymph node, contrast-enhanced CT was performed to confirm the enhancement effects prior to arterial injection therapy. For radiotherapy, external irradiation of the entire cervical region on the affected side at 42 Gy (3 Gy/day) was carried out. Resection of the primary tumor and radical neck dissection were performed 4 weeks after preoperative treatment. The subjects were 16 stage-III/-IV patients with cervical lymph node metastasis (23 lymph nodes). When histopathologically evaluating the primary focus, the response rates were 87.5% in grade-IIb or higher patients and 68.8% in grade-III or higher patients. Concerning the resected cervical lymph nodes, the response rates were 87.0% in grade-IIb or higher patients and 69.6% in grade-III or higher patients. These results showed that arterial injection therapy, which is employed in our department, was effective for cervical lymph nodes, suggesting its usefulness.