Fibrinogenの純金とチタンへの吸着

洞沢 功子; 鬼沢 徹; 山倉 和典; 中島 三晴; 森 厚二; 新納 亨; 小野 擴仁; 小暮 亮雅; 溝口 利英; 伊藤 充雄

doi:10.18939/jjdm.25.3_229

Original Articles

The Adsorption Phenomenon of Fibrinogen on Gold and Titanium

Noriko HORASAWA, Toru ONIZAWA, Kazunori YAMAKURA, Mitsuharu NAKAJIMA, Koji MORI, Toru NIRO, Hirohito ONO, Akinori KOGURE, Toshihide MIZOGUCHI, Michio ITO

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Keywords: Biomaterial, Adsorption, Metal, Protein, Fibrinogen

JOURNAL FREE ACCESS

2006 Volume 25 Issue 3 Pages 229-235

DOI https://doi.org/10.18939/jjdm.25.3_229

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Abstract

The objective of the study was to investigate adsorption of the adhesive protein fibrinogen on plates of gold and titanium as a first step in the analysis of reactions at the interface between tissues and dental alloys. For the adsorption test, each gold and titanium plate was immersed in fibrinogen solutions at varying concentrations, and maintained at 37℃ for 1, 3 and 5 days. The amount of adsorbed fibrinogen as a function of the fibrinogen concentration and immersion conditions was analyzed quantitatively using a biochemical method. Surfaces of gold and titanium, after, performing adsorption and desorption tests, were observed by means of an atomic force microscope under aqueous conditions. The results showed that adsorption of fibrinogen was weak on gold but relatively strong on titanium. In conclusion, fibrinogen attaches mainly to gold by physical adsorption, but to titanium by chemical adsorption.

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