In a previous study, dentures processed with injection type microwave-curing resin and conventional type microwave-curing resin showed different dimensional accuracy. The purpose of this study was to elucidate the variables that exert the influence on dimensional change. The variables of denture base material, investment material, molding technique, microwave exposing time and bench cooling time were analyzed with robust design methods, and the conditions imposed in the study were compared. The variables affected dimensional accuracy for complete denture processed with microwave-curing resin were denture base material, investment material and microwave exposing time.