Among spherically moulded specimens of Type III gold alloy, Ag-Au-Pd alloy and Ti were combined. One was fixed at the bottom of a glass vessel and the other was gyrated freely at 240 rpm for 5 days. After gyration, metal dissolution and cell viability in the extracts and filtrates were measured. There was a difference in the dissolution of constituent metallic elements between the extracts from a combination of two specimens, but no significant difference in cell viability.Although the Cu dissolution with the Type III gold alloy combination was the largest, the amount was only 0.83 ppm. Dissolution of other elements was less than 0.1 ppm.In the combination of the two specimens, gyrating the Type III alloy had the largest effect, while gyrating Ti had the smallest effect.