Recently, home pharmacists have been required to promote multiprofessional cooperation for home medical care. However, the above-mentioned practice among home pharmacists has been less reported. We experienced a case of treatment-resistant hypertension in an elderly female patient, which was intervened by home pharmacists cooperating with a home doctor and a nurse as part of home medical care. Consequently, this resulted in an improvement of blood pressure and a reduction of antihypertensive agents. Since hypertension, complicated by depression, was suspected based on the information shared with the home doctor and nurse, we suggested a prescription of escitalopram. Escitalopram treatment resulted in the improvement of blood pressure and reduction of antihypertensive agents. Furthermore, the Quick Inventory of Depressive Symptomatology score was decreased after escitalopram treatment. In this case, the practice by home pharmacists is considered useful improving the quality of home medical care.