I collected answers to an 64-item questionnaire about the lifestyle related symptoms from 489 Japanese subjects. For part of the subjects (n=868), DNA was also extracted and three SNPs in the genes UCP1, ADRB2, and ADRB3 were genotyped. The association analysis between the questionnaire and the 3 SNPs were performed by a cumulative logistic regression model. As a result, the presence of neck stiffness was associated with genetic variation of rs1800592 in UCP1 gene (regression coefficient is 0.351, P value is 0.003). I also found several associations of UCP1 with the ease of producing a phlegm, cough, and difficulty with constipation. An ease of palpitations and an eye pain were associated with ADRB3 and ADRB2, respectively. Especially, a significant association with UCP1 was suggested for a combination of several questionnaire items (regression coefficient is 0.458, P value is 0.00003). My results suggest that personalized health guidance based on genetic testing can be helpful.