We isolated antioxidative compounds from ginger (Zingiber officinale Roscoe) based on the inhibitory activity toward lipid peroxidation of a rat brain homogenate which has been proposed to mimic the tissue damage by free radicals. The structures of these antioxidative compounds were determined by EIMS and NMR spectral data 1D (¹H-and ¹³C-NMR) and 2D (¹H-¹H COSY, HMQC and HMBC) to be paradol, curcumin, gingerol, hexahydrocurcumin, gingereron A and [4] -gingerol. Freeze-dried ginger powder was heat treated by boiling and frying, and the change in the antioxidative activity was examined. The heat treatment had no effect on the antioxidative activity.