The patient was a 66-year-old woman who was referred to our Department of Otolaryngology at Kansai Medical University with the suspicion of nasal tumor and underwent endoscopic nasal surgery in 2013. Recurrence was observed in the palate in 2017, and subtotal palate resection was performed by an otolaryngologist. After the surgery, she was referred to our department and treated with a dento-maxillary prosthesis. In the same year, a partial maxillary resection was performed by the otolaryngologist as an additional procedure; therefore, the dento-maxillary prosthesis was refabricated. Furthermore, because another recurrence was observed, subtotal maxillary resection and rectus abdominis musculocutaneous flap reconstruction were performed. As additional surgery was repeated, the range of maxillary defects expanded, and it became more difficult to fabricate the prosthesis. Due to the oral environment, it became extremely difficult to fabricate the prosthesis. Eventually, although sufficient improvement was not achieved for speech and masticatory disorders, patient satisfaction with the improvement of esthetic disorders was obtained.