Mandibular tumor resections require removal of surrounding tissues to ensure clear margins. Reconstructive procedures should be performed based on surgical and prosthetic coordination. Social and psychological issues relating to the impact of successful surgical and prosthetic procedures are important for improving quality of life. This paper presents a case report of prosthetic reconstruction following large resection in the mandible, using an unique prosthetic design. The design of the prosthesis and its procedure are described, and patients’ evaluation of oral function is also reported using the visual analog scale method.