Purpose: The aim of the present study was to examine floor nurses’ discharge guidance provided for facilitating daily living of patients undergoing Home Oxygen Therapy (HOT) and to extract factors related to discharge guidance.

Method: Questionnaires were mailed to floor nurses who were responsible for providing discharge guidance at regional medical support hospitals in the capital region.

Results: Eighty-six floor nurses at 21 hospitals responded to the questionnaires (the recovery rate was 62.3%), and the number of valid responses was 68 (71.9%). Five factors related to discharge guidance were extracted. These were dietary habits and nutrition, means of transportation, living environment, ways to improve daily living, and maintaining personal hygiene. Floor nurses, who participated in a workshop on discharge guidance and were primarily responsible for patients undergoing HOT, provided appropriate discharge guidance for dietary habits and nutrition and means of transportation. Floor nurses, who worked at hospitals that held a workshop on HOT, provided appropriate discharge guidance for maintaining personal hygiene.

Discussion: For floor nurses to provide appropriate discharge guidance for facilitating daily living of patients undergoing HOT, they need to frequently practice discharge guidance as a part of their daily duties, cooperate with outpatient departments, and have access to educational opportunities, such as study sessions to improve the nurses’ expertise.