A granular cell tumor is relatively rare soft tissue benign tumor, characterized by the acidophilic granules in cytoplasm. In this paper, a case of granular cell tumor occurring in buccal mucosa of a 65-year-old woman was presented. Intracytoplasmic granules were intensely immunostained with alpha-1-antitrypsin and S-100 protein showed weak reaction. No reaction to neuron specific enolase, actin and keratin was observed. According to these results, the tumor cell was suspected to be of histiocytic origin.