The Society for Scientific Exploration (SSE) congratulate the International Society of Life Information Science (ISLIS) on 25 years of outstanding science. Happy 25th Anniversary! The study of scientific anomalies has made constant progress in research and recognition in recent years. Acceptance has intensified in the general population and increasingly penetrated the minds of many mainstream researchers; especially younger professionals. Inter-disciplinary collaborations and societies like the SSE are helping to drive discovery and understanding. A shift is occurring from validating that anomalies are real; to second-order exploration of mechanisms.