Search for novel odor-sensing materials is vital for the general field of artificial olfaction using acoustic-wave based sensors such as QCMs. Here we present recent result of our ongoing study on application of pegylated lipids as sensing film supports for QCM odor-sensors. The method presented herein is based on chemisorption of lipopolymer- or lipid-lipopolymer cushion and subsequent physisorption of selected, amphiphilic gas chromatography (GC) materials. The GC materials physisorb onto the supports owing to hydrophobic interaction of their tails with lipid moieties of the lipopolymeric supports. The method allows for fabrication of hybrid QCM odor-sensors with high sensitivity to odorants without much acoustic loss, despite the liquid or semi liquid state of the GC materials used. The sensors are also capable of very good discrimination among odorant samples at various concentrations.