Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance

Tong Wu; Fang Zhang; Qiu Yang; Yuwei Zhang; Qinhui Liu; Wei Jiang; Hongyi Cao; Daigang Li; Shugui Xie; Nanwei Tong; Jinhan He

doi:10.1507/endocrj.EJ16-0472

ORIGINALS

Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance

Tong Wu, Fang Zhang, Qiu Yang, Yuwei Zhang, Qinhui Liu, Wei Jiang, Hongyi Cao, Daigang Li, Shugui Xie, Nanwei Tong, Jinhan He

Author information

Tong Wu
Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China
Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China
Fang Zhang
Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China
Qiu Yang
Division of Endocrinology and Metabolism, The fifth Hospital of Chengdu, Chengdu, Sichuan 610041, China
Yuwei Zhang
Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China
Qinhui Liu
Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China
Wei Jiang
Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China
Hongyi Cao
Division of Endocrinology and Metabolism, The fifth Hospital of Chengdu, Chengdu, Sichuan 610041, China
Daigang Li
The Yinchao Community Hospital of Chengdu, Chengdu, Sichuan 610041, China
Shugui Xie
Chengdu Aerospace Hospital, Chengdu, Sichuan 610041, China
Nanwei Tong
Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China
Jinhan He
Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China
Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China

Keywords: Type 2 diabetes, Insulin resistance, Mesencephalic astrocyte-derived neurotrophic factor, Endoplasmic reticulum stress

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2017 Volume 64 Issue 4 Pages 403-410

DOI https://doi.org/10.1507/endocrj.EJ16-0472

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Abstract

Evidence has shown that endoplasmic reticulum (ER) stress was involved in the progression to type 2 diabetes mellitus (T2DM) and development of insulin resistance. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a novel secreted protein upregulated by ER stress. This study aimed to assess serum level of MANF in normal glucose tolerance (NGT) participants and newly diagnosed prediabetic and T2DM patients. A total of 257 participants with NGT, newly diagnosed prediabetes or T2DM were recruited from Yinchao and Hangtian communities of Chengdu, Sichuan, China. Serum MANF level was quantified by enzyme-linked immunosorbent assay (ELISA). The mean age for the 257 participants (147 females) was 62±8 years (range 44-78): 71 with NGT, 115 with newly diagnosed prediabetes and 71 with T2DM. Mean serum MANF level was significantly higher with newly diagnosed prediabetes and T2DM than NGT (2.89±1.09 and 3.03±1.73 vs 2.13±1.37 ng/mL, both p<0.001). MANF level was not correlated with insulin sensitivity indexes (homeostasis model assessment for insulin resistance [HOMA-IR], Matsuda Index and quantitative insulin sensitivity check index [QUICKI]) for NGT and T2DM participants but was correlated with such indexes for prediabetes patients. We concluded that serum MANF level was higher in patients with newly diagnosed prediabetes and T2DM than in NGT controls. MANF appears to be associated with Matsuda Index, QUICKI and HOMA-IR in prediabetes patients.

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