Objective: SARS（severe acute respiratory syndrome）-CoV2 emerged at the end of 2019, and the infection quickly spread throughout the world. The mRNA vaccines against an unknown infectious disease was developed at an astonishing speed, and in Japan, vaccination was actively promoted for the public. However, rheumatoid arthritis（RA）patients often use immunosuppressive drugs, and expectations and concerns about vaccines were swirling. Therefore, we conducted a survey of RA patientsʼ awareness of vaccination and attempted to identify risk factors for the occurrence of adverse events（AEs）by vaccination.

Subjects and methods: Of the 479 RA patients who visited Shirahama Hamayu Hospital, a questionnaire survey was conducted between February 4, 2022 and May 31, 2022. A logistic analysis was also conducted with local and systemic AEs as endpoints.

Results: Nearly 90% of patients received two or more doses of vaccine in a population with a median age of 71.2 years. Pain was the most common administration site reaction, and malaise was the most common systemic reaction. Logistic analysis revealed that age was extracted as a significant inhibitory factor for the occurrence of AEs.

Conclusion: RA patients were vaccinated in the same way as the general population in accordance with government directives, and age alone was a significant influencing factor for AEs, with no effect by the medicines used or disease activity.