高IgG4血症及びリンパ節へのIgG4陽性形質細胞浸潤を認めた抗SS-A抗体陰性/抗SS-B抗体陽性シェーグレン症候群の1例

Yoshiro Horai; Yasumori Izumi; Tohru Michitsuji; Nozomi Iwanaga; Yoshikazu Nakashima; Hideki Nakamura; Atsushi Kawakami; Masahiro Ito

doi:10.14961/cra.30.276

Anti-SS-A antibody-negative/anti-SS-B antibody-positive Sjögrenʼs syndrome with increased serum concentration and lymph node infiltration of immunoglobulin G4: a case report

Yoshiro Horai, Yasumori Izumi, Tohru Michitsuji, Nozomi Iwanaga, Yoshikazu Nakashima, Hideki Nakamura, Atsushi Kawakami, Masahiro Ito

Author information

Keywords: anti-SS-B-antibody, immunoglobulin G4, Sjögrenʼs syndrome

JOURNAL FREE ACCESS

2018 Volume 30 Issue 4 Pages 276-283

DOI https://doi.org/10.14961/cra.30.276

Details

Abstract

A man in his sixties was referred to our hospital with numbness in the extremities and presented with systemic lymph node swelling including prominent immunoglobulin（Ig）G4-positive cell infiltration as well as an elevated serum IgG4 level. He lacked subjective sicca symptoms but was positive for anti-SS-B antibody. Periductal focal mononuclear cell infiltration in labial salivary gland biopsy specimen led to the diagnosis of Sjögren’s syndrome. This is the first case of a patient with anti-SS-A antibody-negative/anti-SS-B antibody-positive Sjögren’s syndrome concomitant with increased serum and lymph node IgG4.

Corresponding author

Register with J-STAGE for free!