This invited review aimed to understand bone quality and bone response to mechanical stimuli based on scientific information from research. Our previous research using several types of animals were selected in this review. Repetitive mechanical loads via the implant significantly changed degree of osseointegration, bone volume, bone mineral density and bone quality around the implant. The specific design controlling bone quality was identified under mechanical loaded-conditions. Bone quality is completely different from bone mineral density. The specific neck design significantly changes bone quality around the implant under mechanical loaded-conditions.