This paper introduces the concept of 'space use' that means the vertical distribution of floor use, and examines and analyzes the transition of the space use in Gobanwari-district in Nagoya CBD from 1988 to 1998. First, existing studies concerning geography, architecture and urban planning fields are reviewed, then the concept of 'space use' is shown. Schematic models on space use in Nagoya CBD are proposed. Results of a factor analysis on space use transition suggest the influences of distance from Sakae crossroad. Specialization trends of CBD functions (not only horizontal but vertical) in each sub-district are examined.